• Researchers Hope Peptide Treatment Could Slow COVID

    A group of Israeli researchers have launched a Phase II study of a drug that they believe could keep patients off mechanical ventilation and speed their recovery. The trial, which is being collectively run by Ziv and Rambam medical centers with researchers from Bar-Ilan University and Technion-Israel Institute of Technology, is examining the use of a drug based on a naturally occurring peptide called angiotensin 1-7 to help counter the impact of COVID-19 on the lungs • Full Story

    Jerusalem Post

    A group of Israeli researchers have launched a Phase II study of a drug that they believe could keep patients off mechanical ventilation and speed their recovery. The trial, which is being collectively run by Ziv and Rambam medical centers with researchers from Bar-Ilan University and Technion-Israel Institute of Technology, is examining the use of a drug based on a naturally occurring peptide called angiotensin 1-7 to help counter the impact of COVID-19 on the lungs.

    A peptide is a set of amino acids.

    Coronavirus enters a person’s cells through angiotensin-converting enzyme 2 (ACE2) receptors. These same receptors produce angiotensin 1-7, explained Dr. Karl Skorecki, dean of the Azrieli Faculty of Medicine of Bar-Ilan University in the Galilee. Angiotensin 1-7 is a protein that is naturally produced in the body and is responsible for preventing cell proliferation and inflammation. “When the enzyme is busy acting as a receptor, it can no longer do what it is supposed to do, which is make angiotensin 1-7,” Skorecki said. “The hope is that by replenishing this peptide, their lungs will get back what the virus nefariously took away from them.”

    Around 3% of all people who contract coronavirus in Israel are hospitalized, and many do not respond to what have become traditional steroid or antiviral drug treatments.
    The trial is using TXA127, a pharmaceutical formulation of angiotensin 1-7 developed by the US company Constant Therapeutics LLC.

    The CEO of the company, Rick Franklin, said that “I am proud of my Jewish roots and of partnering with Rambam, Ziv, Bar-Ilan and the Technion, which are world-renowned institutions.”
    Because the protein is a biological substance, the likelihood of it causing side effects is low, according to Skorecki.
    The Phase II trial was approved by the Health Ministry and will involve 120 hospitalized COVID-19 patients whose condition is defined as moderate. Sixty patients will receive the treatment and 60 a placebo. So far, more than a dozen patients have enrolled in the trial.

    The idea to test angiotensin 1-7 was generated by the Technion’s Prof. Zaid Abassi. “I thought if there was a decrease in this enzyme in the body, maybe external administration of the protein would prevent the complications caused by coronavirus, with an emphasis on improving lung damage,” Abassi explained. “Once the idea came up, a race against the clock began.”

    Skorecki said the hope is that the trial will be completed in the next two to four months. Coronavirus mutations would not affect the effectiveness of treatment, according to Rambam’s Dr. Etty Kruzel. “We are so confident in the results that [Constant Therapeutics] is already recruiting partners to prepare for global manufacturing and distribution.”

    43

    Tags: , ,

    Related Posts:

    *Only proper comments will be allowed
  • Event Calendar

  • Tuesday, Oct 27th, Wedding – Shlome Wolvovsky – CH & Rochel Leah Matusof – Madison, WI @ Oholei Torah
  • Thursday Oct 29th Wedding: Devorah Bennish – Detroit & Mordechai Rubin – London @ Royalty House, MI
  • Sunday, Oct 25th, Sholli Miller – Chicago, IL & Batya Korf – Miami Beach, FL @ Bais Rivka 310 Crown Street
  • Thursday, Oct 22 Wedding: Chaim Boruch Bar-Chaim – CH & Shoshana Pimentelli – CH/TX @ Oholei Torah
  • Thursday, Oct 22 L’Chaim: Sruli Finck – CH & Chaya Mangel – Dayton, OH @ Chovevei Torah 885 Eastern Parkway
  • Tuesday, Oct 20th Wedding: Dovid Kaminetzky – Melbourne, AU & Chaya Okunov – Crown Heights @ Oholei Torah
  • Monday Oct 19 L’Chaim: Ari (Aaron) Levertov – Crown Heights & Debby Rabinowicz – Sao Paulo, Brazil @ Choivevey Torah
  • Monday, Oct 19 2015 Wedding: Mendy Zippel – Salt Lake City, UT & Fraidy Shagalov – Crown Heights @ Oholei Torah
  • Sunday 18th Oct. L’Chaim: Chananya Niassoff – CH & Tzirl Brennan – CH @ Bais Rivkah Crown St
  • Sunday Oct 18th – Wedding: Mendy Edelman – Crown Heights & Sara Lozenik – Miami, FL @ Oholei Torah
  • Tehilim

  • Urgent Tehillim Needed
  • Dov Chaim Ben Rivkah
  • Tzvi Hirsch Ben Guttel
  • Charna Alexandra bas Chana Esther
  • Ettie Bas Alte Miriam
  • Zissel Yehudis Bas Masha
  • Chaim Yosef Yitzchok Ben Sarah Elka
  • Devorah Bas Sarah
  • Boruch Ben Sarah
  • DovBer Ben Dina
  • Lost and Found

  • Lost Men’s Heavy Black Winter Jacket Size Large in 770
  • Lost in 770 before Pesach, a black Bradley Jons long coat size 38R. No lining and no belt. Almost brand new! Please call zalman at 347-788-0749
  • Found black hats outside 770, behind the Hatzalah ambulance
  • lost – Chitas bearing a blessing to Shmuel from Sarge. (Sargent Zvi Fisher z..l.v) geulanow@012.net.il or +1-7869427070
  • LOST: in 770 a black Lenovo Intel core i5 laptop in a dark grey laptop bad together with a WD hard drive, if found please call Zalmy 347-788-0749
  • Found: Maroon Chitas
  • Found: Bag of Clothes
  • Found: Leather-Bound Pink Siddur
  • Lost: Box with Mini Shas from YSP
  • Lost: Rose Gold Bangle/Bracelet
  • Classifieds

  • Cook position for a local Mosad
  • Looking for a cook/kitchen manager
  • Administrator for a local Mosad Experience a must, and preferbiligual a bonus poconosmountains@gmail.com
  • Looking for a cook/kitchen manager Experience a must. poconosmountains@gmail.com
  • ‘Beis Mosiach’s’ to give away for free
  • Private Rooms for Men
  • Newly renovated Basement for rent
  • Judaica Store in Crown Heights is Looking to Hire
  • Looking for Work? Opportunity available, for a quick & efficient typist in Williamsburg. For more info: 201-800-1774
  • Lost in 770 Last Week: Transparant Bag of Tefillin, Rashi, R”T, Chitas – in black/grey 770 pouches